Article
Methionine synthase A2756G polymorphism may predict ulcerative colitis and methylenetetrahydrofolate reductase C677T pancolitis, in Central China.
BMC medical genetics - 13 Aug 2008
Chen Min, Peyrin-Biroulet Laurent, Xia Bing, Guéant-Rodriguez Rosa-Maria, Bronowicki Jean-Pierre, Bigard Marc-André, Guéant Jean-Louis
Abstract excerpt
BACKGROUND: The association of genetic polymorphisms related to metabolism of homocysteine with inflammatory bowel disease has been evidenced in Crohn disease and remains an open question in ulcerative colitis. We evaluated the association of the polymorphisms of MTHFR, MTR, MTRR and TCN2 genes with ulcerative colitis in Central China. METHODS: 168 patients were genotyped for these polymorphisms and compared to...
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