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Article

Linkage study of fibrinogen levels: the Strong Heart Family Study.

BMC medical genetics - 12 Aug 2008

Best Lyle G, North Kari E, Li Xia, Palmieri Vittorio, Umans Jason G, MacCluer Jean, Laston Sandy, Haack Karin, Goring Harald, Diego Vincent P, Almasy Laura, Lee Elisa T, Tracy Russell P, Cole Shelley

Abstract excerpt

BACKGROUND: The pathogenesis of atherosclerosis involves both hemostatic and inflammatory mechanisms. Fibrinogen is associated with both risk of thrombosis and inflammation. A recent meta-analysis showed that risk of coronary heart disease may increase 1.8 fold for 1 g/L of increased fibrinogen, independent of traditional risk factors. It is known that fibrinogen levels may be influenced by demographic,...

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Identifiers

PMID: 18700015
DOI: 10.1186/1471-2350-9-77
PMCID: PMC2518547

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Linkage study of fibrinogen levels: the Strong Heart Family Study.PMID 18700015Read ↗

A genome-wide search for genes affecting circulating fibrinogen levels in the Framingham Heart Study.Semantic proximity Read ↗

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.Semantic proximity Read ↗

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.Semantic proximity Read ↗

Assessment of genetic determinants of the association of γ' fibrinogen in relation to cardiovascular disease.Semantic proximity Read ↗

Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.Semantic proximity Read ↗

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.Semantic proximity Read ↗

Identification of gene-gene and gene-environment interactions within the fibrinogen gene cluster for fibrinogen levels in three ethnically diverse populations.Semantic proximity Read ↗

Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.Semantic proximity Read ↗

Genetic and environmental contributions to cardiovascular disease risk in American Indians: the strong heart family study.Semantic proximity Read ↗

Genetic contribution to variation in atherothrombotic phenotypes in the Asian Indian population. The Indian Atherosclerosis Research Study.Semantic proximity Read ↗

Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the Candidate Gene Association Resource (CARe).Semantic proximity Read ↗

Association between patterns of nucleotide variation across the three fibrinogen genes and plasma fibrinogen levels: the Coronary Artery Risk Development in Young Adults (CARDIA) study.Semantic proximity Read ↗

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