Article
A new allele of the lurcher gene, lurcherJ.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 1997
De Jager P L, Zuo J, Cook S A, Heintz N
Abstract excerpt
A new neurological mouse mutation that arose spontaneously in a BALB/cByJ stock displays a semidominant pattern of inheritance. In the heterozygote, this mutation results in an early loss of Purkinje cells in the cerebellum, which is followed by the overt symptom of an ataxic gait first observed at postnatal day 13 (P13). A portion of animals homozygous for the mutation die within P0; the remaining homozygotes...
Topics
- Alleles
- Animals
- Animals, Newborn
- Chromosome Mapping
- Crosses, Genetic
- Genetic Linkage
- Genetic Markers
- Heterozygote
- Mice
- Mice, Inbred BALB C
- Mice, Inbred Strains
- Mice, Neurologic Mutants
- Motor Activity
- Nerve Degeneration
- Purkinje Cells