Article

Genome-wide association study of copy number variations in Parkinson’s disease

2024-08-22

Abstract excerpt

<h4>Objective</h4> To investigate the impact of copy number variations (CNVs) on Parkinson’s disease (PD) pathogenesis using genome-wide data and explore their role in sporadic PD. <h4>Methods</h4> We analyzed CNV data from 11,035 PD patients (including 2,731 early-onset PD (EOPD)) and 8,901 controls from the COURAGE-PD consortium using a sliding window CNV-GWAS and genome-wide burden analysis. The independent d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 643459bf-a47e-5a72-bd0f-5daf7f40f351
DOI: 10.1101/2024.08.21.24311915

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study of copy number variations in Parkinson’s diseaseDOI 10.1101/2024.08.21.24311915Read

High-resolution arrays reveal burden of copy number variations on Parkinson disease genes associated with increased disease risk in random cohorts.Semantic proximity Read

Copy number variability in Parkinson's disease: assembling the puzzle through a systems biology approach.Semantic proximity Read

High-depth whole-genome sequencing identifies structure variants, copy number variants and short tandem repeats associated with Parkinson’s diseaseSemantic proximity Read

Integrated Sequencing & Array Comparative Genomic Hybridization in Familial Parkinson’s DiseaseSemantic proximity Read

Comprehensive genetic screening of the South African Parkinson’s disease study collection using the NeuroBooster arraySemantic proximity Read

Heterozygous <i>PRKN</i> mutations are common but do not increase the risk of Parkinson’s diseaseSemantic proximity Read

Genetic landscape of Parkinson’s disease and related diseases in LuxembourgSemantic proximity Read

High-depth whole-genome sequencing identifies structure variants, copy number variants and short tandem repeats associated with Parkinson’s diseaseSemantic proximity Read

Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder.Semantic proximity Read

Analysis of Heterozygous PRKN Variants and Copy-Number Variations in Parkinson's Disease.Semantic proximity Read

A comprehensive analysis of deletions, multiplications, and copy number variations in PARK2.Semantic proximity Read

Copy number variation in familial Parkinson disease.Semantic proximity Read