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Article

An approach to finding brain-situated mutations in sporadic Parkinson's disease.

Parkinsonism & related disorders - 1 Jan 2012

Pamphlett Roger, Morahan Julia M, Luquin Natasha, Yu Bing

Abstract excerpt

Sporadic Parkinson's disease (PD) is thought to have a major genetic component, but the variants involved remain mostly unknown. One possible reason for the difficulty in finding mutations underlying PD is that rare predominantly brain-situated somatic mutations underlie the disease; these mutations would be missed by analysing blood DNA only. To test the feasibility of looking for somatic mutations in PD brain...

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Identifiers

PMID: 21917499
DOI: 10.1016/j.parkreldis.2011.08.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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