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Article

Intriguing balancing selection on the intron 5 region of LMBR1 in human population.

PloS one - 13 Aug 2008

He Fang, Wu Dong-Dong, Kong Qing-Peng, Zhang Ya-Ping

Abstract excerpt

BACKGROUND: The intron 5 of gene LMBR1 is the cis-acting regulatory module for the sonic hedgehog (SHH) gene. Mutation in this non-coding region is associated with preaxial polydactyly, and may play crucial roles in the evolution of limb and skeletal system. METHODOLOGY/PRINCIPAL FINDINGS: We seq...

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Source

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Identifiers

PMID: 18698406
DOI: 10.1371/journal.pone.0002948
PMCID: PMC2492787

Genes

LMBR1
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18698406-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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