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Article

Positive selection on the osteoarthritis-risk and decreased-height associated variants at the GDF5 gene in East Asians.

PloS one - 1 Jan 2012

Wu Dong-Dong, Li Gui-Mei, Jin Wei, Li Yan, Zhang Ya-Ping

Abstract excerpt

GDF5 is a member of the bone morphogenetic protein (BMP) gene family, and plays an important role in the development of the skeletal system. Variants of the gene are associated with osteoarthritis and height in some human populations. Here, we resequenced the gene in individuals from four geographically separated human populations, and found that the evolution of the promoter region deviated from neutral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22905146
DOI: 10.1371/journal.pone.0042553
PMCID: PMC3419199

Genes

GDF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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