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Role of Wnt signaling in the development of type 2 diabetes.

Vitamins and hormones - 1 Jan 2009

Bordonaro Michael

Abstract excerpt

Type 2 diabetes is characterized by insulin resistance, insulin deficiency, and hyperglycemia. Susceptibility to type 2 diabetes has been linked to Wnt signaling, which plays an important role in intestinal tumorigenesis. Carriers of variants of the transcription factor 7-like 2 gene, an important component of the Wnt pathway, are at enhanced risk for developing type 2 diabetes. The modulation of proglucagon...

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Colorectal Neoplasms
Diabetes Mellitus, Type 2
Gene Expression Regulation
Genetic Variation
STAT1 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

TCF Transcription Factors

Transcription Factor 7-Like 2 Protein

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PMID: 19251050
DOI: 10.1016/S0083-6729(08)00619-5

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