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The Role of Wnt3a/β-Catenin/TCF7L2 Pathway in Diabetes and Cardiorenal Complications

20 Dec 2024

Abstract excerpt

BACKGROUND: Diabetes mellitus is a prevalent chronic disease that is becoming increasingly common worldwide and can lead to a number of dangerous complications. The Wnt signaling pathway is important for the onset and progression of diabetes. Wnt3a is a typical Wnt ligand that can increase the stability of β-catenin, control TCF7L2 expression, promote β-cell proliferation, and reduce apoptosis. SUMMARY: The...

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Share to Chronic Kidney Disease and Diabetes
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PMID: 39709946
DOI: 10.1159/000543145

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