Article
Appropriate data cleaning methods for genome-wide association study.
Journal of human genetics - 1 Jan 2008
Miyagawa Taku, Nishida Nao, Ohashi Jun, Kimura Ryosuke, Fujimoto Akihiro, Kawashima Minae, Koike Asako, Sasaki Tsukasa, Tanii Hisashi, Otowa Takeshi, Momose Yoshio, Nakahara Yasuo, Gotoh Jun, Okazaki Yuji, Tsuji Shoji, Tokunaga Katsushi
Abstract excerpt
Genome-wide association studies (GWAS) using a large number of single nucleotide polymorphisms (SNPs) have successfully been applied to identify genetic variants of common diseases. However, genotyping using the new array technologies is often associated with spurious results that could unfavorably affect analyses of GWAS. Consequently, data cleaning is of paramount importance in excluding spurious genotyping...
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