Article
Technical reproducibility of genotyping SNP arrays used in genome-wide association studies.
PloS one - 1 Jan 2012
Hong Huixiao, Xu Lei, Liu Jie, Jones Wendell D, Su Zhenqiang, Ning Baitang, Perkins Roger, Ge Weigong, Miclaus Kelci, Zhang Li, Park Kyunghee, Green Bridgett, Han Tao, Fang Hong, Lambert Christophe G, Vega Silvia C, Lin Simon M, Jafari Nadereh, Czika Wendy, Wolfinger Russell D, Goodsaid Federico, Tong Weida, Shi Leming
Abstract excerpt
During the last several years, high-density genotyping SNP arrays have facilitated genome-wide association studies (GWAS) that successfully identified common genetic variants associated with a variety of phenotypes. However, each of the identified genetic variants only explains a very small fraction of the underlying genetic contribution to the studied phenotypic trait. Moreover, discordance observed in results...
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