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Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease

11 Aug 2008

Abstract excerpt

Telomere dysfunction limits the proliferative capacity of human cells by activation of DNA damage responses, inducing senescence or apoptosis. In humans, telomere shortening occurs in the vast majority of tissues during aging, and telomere shortening is accelerated in chronic diseases that increase the rate of cell turnover. Yet, the functional role of telomere dysfunction and DNA damage in human aging and...

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Share to Genetics, Aging, and Longevity in Model Organisms
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Share to Telomeres, Telomerase, and Senescence

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PMID: 18695223
DOI: 10.1073/pnas.0801457105

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