Article

Proteomic and transcriptomic analysis of human CD8+ T lymphocytes over-expressing telomerase.

2007-03-01

Abstract excerpt

Human T lymphocytes have a finite life span resulting from progressive telomere shortening that occurs at each cell division, eventually leading to chromosomal instability. It has been shown that ectopic expression of the human telomerase reverse transcriptase (hTERT) gene into various human cells results in the extension of their replicative life span, without inducing changes associated with transformation. Howe...

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Literature Corpus work: 5e83f7cd-5702-555c-9804-58f1bf7914fd
DOI: 10.1002/prca.200600835

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