Article
Design and analysis issues in genome-wide somatic mutation studies of cancer.
Genomics - 1 Jan 2009
Parmigiani Giovanni, Boca Simina, Lin Jimmy, Kinzler Kenneth W, Velculescu Victor, Vogelstein Bert
Abstract excerpt
The availability of the human genome sequence and progress in sequencing and bioinformatic technologies have enabled genome-wide investigation of somatic mutations in human cancers. This article briefly reviews challenges arising in the statistical analysis of mutational data of this kind. A first challenge is that of designing studies that efficiently allocate sequencing resources. We show that this can be...
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