Article
[Correlation between hemoglobin F levels and single nucleotide polymorphism at BCL11A gene rs11886868 locus in β-thalassemia patients].
Zhongguo shi yan xue ye xue za zhi - 1 Jun 2012
Chen Qun-Rong, Sun Shun-Chang, Peng Yun-Sheng, Wang Qing, Mo Bao-Mei
Abstract excerpt
This study was aimed to analyze hemoglobin F (HbF) level and single nucleotide polymorphisms at rs11886868 locus of BCL11A gene in β-thalassemia patients, and to explore correlation between them. 89 mild β-thalassemia patients with known mutations were registered, and HbF levels were determined by capillary electrophoresis. Genomic DNA was extracted from peripheral leukocytes, fragment including rs11886868 locus...
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