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Article

Association of polymorphisms in the HBG1-HBD intergenic region with HbF levels.

Journal of clinical laboratory analysis - 1 Jun 2020

Hu Li, Huang Ling, Han Yuanyuan, Jin Tingting, Liu Juan, Jiang Minmin, Liu Xingmei, Li Yuanyuan, Han Wenping, An Bangquan, Huang Shengwen

Abstract excerpt

BACKGROUND: Increased levels of fetal hemoglobin (HbF) can improve the clinical course of the patients with sickle cell anemia (SCA) or β-thalassemia. The HBG1-HBD intergenic region plays an important role in this process. However, very few studies investigated whether the variations in this region have an effect on HbF expression. METHODS: We retrieved all the SNP data in the HBG1-HBD intergenic region and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32068918
DOI: 10.1002/jcla.23243
PMCID: PMC7307336

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