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Article

Controlling the mass action of α‐synuclein in Parkinson’s disease

8 Aug 2008

Abstract excerpt

Parkinson's disease (PD) is an age-related neurodegenerative disease with unknown etiology. Growing evidence from genetic, pathologic, animal modeling, and biochemical studies strongly support the theory that abnormal aggregation of alpha-synuclein plays a critical role in the pathogenesis of PD. Protein aggregation is an alternative folding process that competes with the native folding pathway. Whether or not a...

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PMID: 18691382
DOI: 10.1111/j.1471-4159.2008.05612.x

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