Article
Overexpression of an N-terminally truncated isoform of the nuclear receptor coactivator amplified in breast cancer 1 leads to altered proliferation of mammary epithelial cells in transgenic mice.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2005
Tilli Maddalena T, Reiter Ronald, Oh Annabell S, Henke Ralf T, McDonnell Kevin, Gallicano G Ian, Furth Priscilla A, Riegel Anna Tate
Abstract excerpt
Amplified in breast cancer 1 (AIB1, also known as ACTR, SRC-3, RAC-3, TRAM-1, p/CIP) is a member of the p160 nuclear receptor coactivator family involved in transcriptional regulation of genes activated through steroid receptors, such as estrogen receptor alpha (ER(alpha)). The AIB1 gene and a more active N-terminally deleted isoform (AIB1-Delta3) are overexpressed in breast cancer. To determine the role of...
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