Role of muscarinic receptors in the activity of N-desmethylclozapine: reversal of hyperactivity in the phospholipase C knockout mouse.

doi:10.1097/FBP.0b013e32830c3669

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Article

Role of muscarinic receptors in the activity of N-desmethylclozapine: reversal of hyperactivity in the phospholipase C knockout mouse.

Behavioural pharmacology - 1 Sept 2008

Gray Laura, McOmish Caitlin, Scarr Elizabeth, Dean Brian, Hannan Anthony J

Abstract excerpt

Activity of the cholinergic muscarinic system is associated with modulation of locomotor activity, although the precise mechanism remains unclear. The phospholipase C-beta1 knockout mouse displays both M1 muscarinic receptor dysfunction and a hyperactive locomotor phenotype. This mouse serves as an ideal model for the analysis of muscarinic modulation of locomotor activity. The clozapine metabolite...

Topics

Animals
Clozapine
Dose-Response Relationship, Drug
Drug Synergism
Genotype
Mice
Mice, Knockout
Motor Activity
Muscarinic Antagonists
Phenotype
Phospholipase C beta
Pirenzepine
Receptor, Muscarinic M1

Source

Open in PubMed

Identifiers

PMID: 18690108
DOI: 10.1097/FBP.0b013e32830c3669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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