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Article

Structural and dynamical effects of targeted mutations on μO-Conotoxin MfVIA: Molecular simulation studies.

Journal of molecular graphics & modelling - 1 Jan 2021

Zhao Lina, Barber Lisa M, Hung Andrew

Abstract excerpt

Conotoxins are a group of cysteine-rich, neurotoxic peptides isolated from the venom of marine cone snails. MfVIA is a member of the μO-conotoxin family, and acts as an inhibitor of subtype 1.8 voltage-gated sodium ion channels (NaV1.8). The unique selectivity of MfVIA as an inhibitor of NaV1.8 makes it an ideal peptide for elucidation of the physiological functions of this voltage-gated ion channel. Previous...

Topics

Conotoxins
Molecular Docking Simulation
Molecular Dynamics Simulation
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33130390
DOI: 10.1016/j.jmgm.2020.107777

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