Article
Exon expression arrays as a tool to identify new cancer genes.
PloS one - 20 Aug 2007
Schutte Mieke, Elstrodt Fons, Bralten Linda B C, Nagel Jord H A, Duijm Elza, Hollestelle Antoinette, Vuerhard Maartje J, Wasielewski Marijke, Peeters Justine K, van der Spek Peter, Sillevis Smitt Peter A, French Pim J
Abstract excerpt
BACKGROUND: Identification of genes that are causally implicated in oncogenesis is a major goal in cancer research. An estimated 10-20% of cancer-related gene mutations result in skipping of one or more exons in the encoded transcripts. Here we report on a strategy to screen in a global fashion for such exon-skipping events using PAttern based Correlation (PAC). The PAC algorithm has been used previously to...
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