Article
How can biologically-based modeling of arsenic kinetics and dynamics inform the risk assessment process? - A workshop review.
Toxicology and applied pharmacology - 1 Nov 2008
Kenyon Elaina M, Klimecki Walter T, El-Masri Hisham, Conolly Rory B, Clewell Harvey J, Beck Barbara D
Abstract excerpt
Quantitative biologically-based models describing key events in the continuum from arsenic exposure to the development of adverse health effects provide a framework to integrate information obtained across diverse research areas. For example, genetic polymorphisms in arsenic metabolizing enzymes can lead to differences in target tissue dosimetry for key metabolites causative in toxic and carcinogenic response....
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