Article
Systems biology tools for toxicology.
Archives of toxicology - 1 Aug 2012
Geenen Suzanne, Taylor Peter Neal, Snoep Jacky L, Wilson Ian D, Kenna J Gerry, Westerhoff Hans V
Abstract excerpt
An important goal of toxicology is to understand and predict the adverse effects of drugs and other xenobiotics. For pharmaceuticals, such effects often emerge unexpectedly in man even when absent from trials in vitro and in animals. Although drugs and xenobiotics act on molecules, it is their perturbation of intracellular networks that matters. The tremendous complexity of these networks makes it difficult to...
Topics
- Animals
- Computer Simulation
- Genotype
- Glutathione
- Humans
- Inactivation, Metabolic
- Liver
- Metabolomics
- Models, Biological
- Pharmacogenetics
- Pharmacokinetics
- Phenotype