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Article

Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45.

Molecular biology of the cell - 1 Oct 2008

Morrison Holly A, Dionne Heather, Rusten Tor Erik, Brech Andreas, Fisher William W, Pfeiffer Barret D, Celniker Susan E, Stenmark Harald, Bilder David

Abstract excerpt

The small GTPase Rab5 has emerged as an important regulator of animal development, and it is essential for endocytic trafficking. However, the mechanisms that link Rab5 activation to cargo entry into early endosomes remain unclear. We show here that Drosophila Rabenosyn (Rbsn) is a Rab5 effector that bridges an interaction between Rab5 and the Sec1/Munc18-family protein Vps45, and we further identify the syntaxin...

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Source

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Identifiers

PMID: 18685079
DOI: 10.1091/mbc.e08-07-0716
PMCID: PMC2555928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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