Article
The SM protein VPS-45 is required for RAB-5-dependent endocytic transport in Caenorhabditis elegans.
EMBO reports - 1 Feb 2007
Gengyo-Ando Keiko, Kuroyanagi Hidehito, Kobayashi Tetsuo, Murate Motohide, Fujimoto Kazushi, Okabe Shigeo, Mitani Shohei
Abstract excerpt
Rab5, a small guanosine triphosphatase, is known to regulate the tethering and docking reaction leading to SNARE (soluble NSF attachment protein receptors)-mediated fusion between endosomes. However, it is uncertain how the signal of the activated Rab5 protein is transduced by its downstream effectors during endosome fusion. Here, we show that the Sec1/Munc18 gene vps-45 is essential for not only viability and...
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