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Article

Extracellular loop C of NPC1L1 is important for binding to ezetimibe.

Proceedings of the National Academy of Sciences of the United States of America - 12 Aug 2008

Weinglass Adam B, Kohler Martin, Schulte Uwe, Liu Jessica, Nketiah Emmanuel O, Thomas Anu, Schmalhofer William, Williams Brande, Bildl Wolfgang, McMasters Daniel R, Dai Kevin, Beers Lindsey, McCann Margaret E, Kaczorowski Gregory J, Garcia Maria L

Abstract excerpt

Niemann-Pick C1-like protein (NPC1L1) mediates the absorption of dietary cholesterol in the proximal region of the intestine, a process that is blocked by cholesterol absorption inhibitors (CAIs), including ezetimibe (EZE). Using a proteomic approach, we demonstrate that NPC1L1 is the protein to which EZE and its analogs bind. Next, we determined the site of interaction of EZE analogs with NPC1L1 by exploiting...

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Share to Anticholesteremic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18682566
DOI: 10.1073/pnas.0800936105
PMCID: PMC2516253

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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