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Article

Synthesis and Modeling of Ezetimibe Analogues.

Molecules (Basel, Switzerland) - 22 May 2021

Salgado Mateo M, Manchado Alejandro, Nieto Carlos T, Díez David, Garrido Narciso M

Abstract excerpt

Ezetimibe is a well-known drug that lowers blood cholesterol levels by reducing its absorption in the small intestine when joining to Niemann-Pick C1-like protein (NPC1L1). A ligand-based study on ezetimibe analogues is reported, together with one-hit synthesis, highlighted in the study. A convenient asymmetric synthesis of (2S,3S)-N-α-(R)-methylbenzyl-3-methoxycarbonylethyl-4-methoxyphenyl β-lactam is described...

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Identifiers

PMID: 34067439
DOI: 10.3390/molecules26113107
PMCID: PMC8196997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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