Article
Genetic tumor syndromes in female cancer: insights into inherited cancer predisposition and clinical implications.
Archives of gynecology and obstetrics - 13 Jan 2026
Krückel Annika, Gocke Julia, Hörner Manuel, Keller Katharina, Müller Carolin, Brückner Lena, Heindl Felix, Hack Carolin C, Beckmann Matthias W, Amann Niklas
Abstract excerpt
A relevant proportion of malignancies predominantly or exclusively affecting women, including breast and gynecologic cancers, is attributable to hereditary tumor syndromes, profoundly impacting cancer risk, prognosis, and therapeutic management. Today, the routine use of comprehensive germline panels has shifted the focus from solely pathogenic BRCA1/2 variants to include numerous pathogenic variants of other...
Topics
- Humans
- Female
- Genetic Predisposition to Disease
- Neoplastic Syndromes, Hereditary
- Genital Neoplasms, Female
- Hereditary Breast and Ovarian Cancer Syndrome
- Breast Neoplasms
- Germ-Line Mutation