Pathology of hereditary breast cancer.

Abstract excerpt

BACKGROUND: Hereditary breast cancer runs in families where several members in different generations are affected. Most of these breast cancers are caused by mutations in the high penetrance genes BRCA1 and BRCA2 accounting for about 5% of all breast cancers. Other genes that include CHEK2, PTEN, TP53, ATM, STK11/LKB1, CDH1, NBS1, RAD50, BRIP1 and PALB2 have been described to be high or moderate penetrance breast...

Topics

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• Family Health
• BRIP1 gene
• Gene Frequency
• Genetic Predisposition to Disease
• Mutation
• BRCA1 Protein