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Article

Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy.

Pharmacogenomics - 1 Aug 2008

Ward Michael B, Kotasek Dusan, McKinnon Ross A

Abstract excerpt

OBJECTIVE: Chemotherapy-induced nausea and vomiting is a significant clinical problem. The 5HT(3) receptor antagonists are effective anti-emetic medications but approximately 30% of patients do not respond. METHOD: We examined the HTR3C gene, which is believed to encode a subunit of the 5HT(3) receptor, for genetic variation and association with anti-emetic efficacy in a group of 70 patients receiving cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18681779
DOI: 10.2217/14622416.9.8.1027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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