Article
An fMRI study of working memory in first-degree unaffected relatives of schizophrenia patients.
Schizophrenia research - 1 Sept 2008
Meda Shashwath A, Bhattarai Manish, Morris Nicholas A, Astur Robert S, Calhoun Vince D, Mathalon Daniel H, Kiehl Kent A, Pearlson Godfrey D
Abstract excerpt
Identifying intermediate phenotypes of genetically complex psychiatric illnesses such as schizophrenia is important. First-degree relatives of persons with schizophrenia have increased genetic risk for the disorder and tend to show deficits on working memory (WM) tasks. An open question is the relationship between such behavioral endophenotypes and the corresponding brain activation patterns revealed during...
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