Article
Genetic liability for bipolar disorder is characterized by excess frontal activation in response to a working memory task.
Biological psychiatry - 15 Sept 2008
Drapier Dominique, Surguladze Simon, Marshall Nicolette, Schulze Katja, Fern Adele, Hall Mei-Hua, Walshe Muriel, Murray Robin M, McDonald Colm
Abstract excerpt
BACKGROUND: There is evidence that patients with bipolar disorder have working memory deficits even during periods of euthymia. The neural basis of such deficits and its relationship with genetic risk remain unclear. We utilized functional magnetic resonance imaging (fMRI) to investigate neural activity in samples of bipolar disorder patients and their unaffected first-degree relatives while performing working...
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