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Article

Interpretation of Immunohistochemistry for Mismatch Repair Proteins is Only Reliable in a Specialized Setting

1 Aug 2008

Abstract excerpt

We examined the validity of immunohistochemistry for mismatch repair (MMR) proteins in colorectal cancer specimens to identify patients at risk for Lynch syndrome (hereditary nonpolyposis colorectal cancer) and patients with sporadic microsatellite instable colorectal cancer. This was assessed by observer agreement for and accuracy of interpretation of immunohistochemistry. Seven pathologists from 5 different...

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PMID: 18677806
DOI: 10.1097/pas.0b013e31816401bb

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