Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies

27 Mar 2019

Abstract excerpt

Context.— Immunohistochemical expression of mismatch repair (MMR) protein is a well-accepted method for routine screening for Lynch syndrome with relatively high sensitivity and specificity. Occasionally, however, immunohistochemistry (IHC) can yield an equivocal result with poor reproducibility and the potential for misdiagnosis. Objective.— To determine the frequency and significance of indeterminate MMR IHC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA gene mutations in cancer
Share to Celiac Disease Research and Management
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30917047
DOI: 10.5858/arpa.2018-0201-oa

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational StudiesPMID 30917047Read ↗

Discordance between germline genetic findings and abnormal tumor immunohistochemistry staining of mismatch repair proteins in individuals with suspected Lynch syndromeSemantic proximity Read ↗

Identification of Cancer Patients with Lynch Syndrome: Clinically Significant Discordances and Problems in Tissue-Based Mismatch Repair TestingSemantic proximity Read ↗

Clinicopathologic Comparison of Lynch Syndrome-associated and "Lynch-like" Endometrial Carcinomas Identified on Universal Screening Using Mismatch Repair Protein Immunohistochemistry.Semantic proximity Read ↗

Unusual Mismatch Repair Immunohistochemical Patterns in Endometrial CarcinomaSemantic proximity Read ↗

Utility of immunohistochemistry for mismatch repair proteins on colorectal polyps in the familial cancer clinic.Semantic proximity Read ↗

Association Between IHC and MSI Testing to Identify Mismatch Repair–Deficient Patients with Ovarian CancerSemantic proximity Read ↗

Universal endometrial cancer tumor typing: How much has immunohistochemistry, microsatellite instability, and MLH1 methylation improved the diagnosis of Lynch syndrome across the population?Semantic proximity Read ↗

Interpretation of Immunohistochemistry for Mismatch Repair Proteins is Only Reliable in a Specialized SettingSemantic proximity Read ↗

Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and MSH2 somatic mutations.Semantic proximity Read ↗

Mismatch Repair Deficiency in Endometrial Cancer: Immunohistochemistry Staining and Clinical ImplicationsSemantic proximity Read ↗

Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors.Semantic proximity Read ↗

Frequent loss of mutation-specific mismatch repair protein expression in nonneoplastic endometrium of Lynch syndrome patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.