Article
Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice.
Immunogenetics - 1 Oct 2008
Zhang Ming-Cai, Furukawa Hiroshi, Tokunaka Kazuhiro, Saiga Kan, Date Fumiko, Owada Yuji, Nose Masato, Ono Masao
Abstract excerpt
Desmosomal cadherins are essential cell adhesion molecules expressed in the epidermis. We identified a mutation of a cadherin superfamily member, namely, desmoglein 4 (Dsg4), in early onset of death (EOD)( hage ) mice with hypotrichosis. The mutation was induced by the insertion of an early transposon II-beta into intron 8 of Dsg4. Mast cell hyperplasia was observed in the skin of EOD( hage ) mice. The abnormally...
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