Article
An APOO Pseudogene on Chromosome 5q Is Associated With Low-Density Lipoprotein Cholesterol Levels.
Circulation - 25 Sept 2018
Montasser May E, O'Hare Elizabeth A, Wang Xiaochun, Howard Alicia D, McFarland Rebecca, Perry James A, Ryan Kathleen A, Rice Kenneth, Jaquish Cashell E, Shuldiner Alan R, Miller Michael, Mitchell Braxton D, Zaghloul Norann A, Chang Yen-Pei C
Abstract excerpt
BACKGROUND: Elevated levels of low-density lipoprotein cholesterol (LDL-C) are a major risk factor for cardiovascular disease via its contribution to the development and progression of atherosclerotic lesions. Although the genetic basis of LDL-C has been studied extensively, currently known genetic variants account for only ≈20% of the variation in LDL-C levels. METHODS: Through an array-based association...
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