Article
Variation in OSBPL10 is associated with dyslipidemia.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 May 2010
Koriyama Hiroshi, Nakagami Hironori, Katsuya Tomohiro, Akasaka Hiroshi, Saitoh Shigeyuki, Shimamoto Kazuaki, Ogihara Toshio, Kaneda Yasufumi, Morishita Ryuichi, Rakugi Hiromi
Abstract excerpt
The oxysterol hypothesis of cholesterol homeostasis states that oxysterol mediates feedback regulation of cholesterol biosynthesis. Oxysterol-binding proteins have been implicated in the control of lipid synthesis and metabolism. In a genome-wide case-control association study in Japanese individuals, we found that the three single-nucleotide polymorphisms (SNPs) with the smallest P-values were located in the...
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