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Article

Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2008

Ulrich Cornelia M, Neuhouser Marian, Liu Amy Y, Boynton Alanna, Gregory Jesse F, Shane Barry, James S Jill, Reed Michael C, Nijhout H Frederik

Abstract excerpt

Low-folate status and genetic polymorphisms in folate metabolism have been linked to several cancers. Possible biological mechanisms for this association include effects on purine and thymidine synthesis, DNA methylation, or homocysteine concentrations. The influence of genetic variation in folate metabolism on these putative mechanisms or biomarkers of cancer risk has been largely unexplored. We used a...

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Source

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Identifiers

PMID: 18628437
DOI: 10.1158/1055-9965.EPI-07-2937
PMCID: PMC3912564

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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