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Caffeine Treatment Prevents Age-Related Changes in Ovine Oocytes and Increases Cell Numbers in Blastocysts Produced by Somatic Cell Nuclear Transfer

3 Aug 2008

Abstract excerpt

Maturation-promoting factor (MPF) and mitogen-activated protein kinase (MAPK) are key regulators of both meiotic and mitotic cycles. Oocytes arrested at metaphase of the second meiotic division (MII) contain high levels of both kinases; however, these activities decline with age. Caffeine (an inhibitor of Myt1/Wee1 activity) can increase MPF and MAPK activities in ovine oocytes; however, the effects of caffeine...

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PMID: 18673075
DOI: 10.1089/clo.2007.0091

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