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Offspring from intracytoplasmic sperm injection of aged mouse oocytes treated with caffeine or MG132

18 Apr 2011

Abstract excerpt

Postovulatory mammalian oocytes age significantly in culture. B6D2F1 or ICR strain mouse oocytes were collected 16 h after hCG injection and then cultured for up to 40 h post hCG at 37 °C under 5% CO(2) in air. After intracytoplasmic sperm injection (ICSI), B6D2F1 and ICR oocytes lost full-term developmental potential by 30 h and 26 h after hCG administration, respectively. However, using supplementation with 10...

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PMID: 21504043
DOI: 10.1002/dvg.20756

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