Article
Regulation of the Warburg effect in early-passage breast cancer cells.
Neoplasia (New York, N.Y.) - 1 Aug 2008
Robey Ian F, Stephen Renu M, Brown Kathy S, Baggett Brenda K, Gatenby Robert A, Gillies Robert J
Abstract excerpt
Malignancy in cancer is associated with aerobic glycolysis (Warburg effect) evidenced by increased trapping of [(18)F]deoxyglucose (FdG) in patients imaged by positron emission tomography (PET). [(18)F]deoxyglucose uptake correlates with glucose transporter (GLUT-1) expression, which can be regulated by hypoxia-inducible factor 1 alpha (HIF-1alpha). We have previously reported in established breast lines that...
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