Article
Localization, regulation, and substrate transport properties of Bpt1p, a Saccharomyces cerevisiae MRP-type ABC transporter.
Eukaryotic cell - 1 Jun 2002
Sharma Kailash Gulshan, Mason Deborah L, Liu Guosheng, Rea Philip A, Bachhawat Anand K, Michaelis Susan
Abstract excerpt
Saccharomyces cerevisiae Bpt1p is an ATP-binding cassette (ABC) protein that belongs to the MRP subfamily and is a close homologue of the glutathione conjugate (GS conjugate) transporter Ycf1p. The function of Bpt1p has previously been evaluated only in vitro, by using nonphysiological substrates. In the present study we examined the localization, regulation, and transport properties of Bpt1p in vivo, as well as...
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