Naturally Occurring Regulatory T cells (CD4⁺, CD25^high, FOXP3⁺) in the Antrum and Cardia are Associated with Higher <i>H. pylori</i> Colonization and Increased Gene Expression of TGF‐β1

Abstract excerpt

BACKGROUND: Helicobacter pylori causes gastric inflammation. Despite the induction of H. pylori-specific B- and T cells, the immune response is not sufficient to clear the infection. Regulatory T cells (Treg cells) suppress the activation and proliferation of antigen-specific T cells and mediate immunologic tolerance. FOXP3 was shown to be expressed in a subset of Treg cells known as 'naturally occurring Treg...

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