Article
Helicobacter pylori induces miR-155 in T cells in a cAMP-Foxp3-dependent manner.
PloS one - 2 Mar 2010
Fassi Fehri Lina, Koch Manuel, Belogolova Elena, Khalil Hany, Bolz Christian, Kalali Behnam, Mollenkopf Hans J, Beigier-Bompadre Macarena, Karlas Alexander, Schneider Thomas, Churin Yuri, Gerhard Markus, Meyer Thomas F
Abstract excerpt
Amongst the most severe clinical outcomes of life-long infections with Helicobacter pylori is the development of peptic ulcers and gastric adenocarcinoma--diseases often associated with an increase of regulatory T cells. Understanding H. pylori-driven regulation of T cells is therefore of crucial clinical importance. Several studies have defined mammalian microRNAs as key regulators of the immune system and of...
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