Article
Telomere abnormalities and chromosome fragility in patients affected by familial papillary thyroid cancer.
The Journal of clinical endocrinology and metabolism - 1 Jul 2012
Cantara Silvia, Pisu Milena, Frau Daniela Virginia, Caria Paola, Dettori Tinuccia, Capezzone Marco, Capuano Serena, Vanni Roberta, Pacini Furio
Abstract excerpt
INTRODUCTION: Genomic instability has been proposed to play a role in cancer development and can occur through different mechanisms including telomere association and telomere loss. Studies carried out in our unit have demonstrated that familial papillary thyroid cancer (fPTC) patients display an imbalance, at the germinal level, in telomere-telomerase complex. AIM: We aimed to verify whether familial fPTC...
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