Article
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nature genetics - 1 Jan 2013
Sausen Mark, Leary Rebecca J, Jones Siân, Wu Jian, Reynolds C Patrick, Liu Xueyuan, Blackford Amanda, Parmigiani Giovanni, Diaz Luis A, Papadopoulos Nickolas, Vogelstein Bert, Kinzler Kenneth W, Velculescu Victor E, Hogarty Michael D
Abstract excerpt
Neuroblastomas are tumors of peripheral sympathetic neurons and are the most common solid tumor in children. To determine the genetic basis for neuroblastoma, we performed whole-genome sequencing (6 cases), exome sequencing (16 cases), genome-wide rearrangement analyses (32 cases) and targeted analyses of specific genomic loci (40 cases) using massively parallel sequencing. On average, each tumor had 19 somatic...
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