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Article

ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells.

The Journal of biological chemistry - 3 Oct 2008

Shimizu Akio, Mammoto Akiko, Italiano Joseph E, Pravda Elke, Dudley Andrew C, Ingber Donald E, Klagsbrun Michael

Abstract excerpt

Class three semaphorins (SEMAs) were originally shown to be mediators of axon guidance that repelled axons and collapsed growth cones, but it is now evident that SEMA3F, for example, has similar effects on tumor cells and endothelial cells (EC). In both human U87MG glioma cells and human umbilical vein EC, SEMA3F induced rapid cytoskeletal collapse, suppressed cell contractility, decreased phosphorylation of...

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Topics

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Share to Cytoskeleton
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glioma

Share to GTPase-Activating Proteins

Share to Proto-Oncogene Proteins c-abl

Share to Receptors, Cell Surface

Share to rhoA GTP-Binding Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 18660502
DOI: 10.1074/jbc.M804520200
PMCID: PMC2555994

Genes

ABL2
NRP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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