Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of actin polymerization and adhesion-dependent cell edge protrusion by the Abl-related gene (Arg) tyrosine kinase and N-WASp.

Biochemistry - 16 Mar 2010

Miller Matthew M, Lapetina Stefanie, MacGrath Stacey M, Sfakianos Mindan K, Pollard Thomas D, Koleske Anthony J

Abstract excerpt

Extracellular cues stimulate the Abl family nonreceptor tyrosine kinase Arg to promote actin-based cell edge protrusions. Several Arg-interacting proteins are potential links to the actin cytoskeleton, but exactly how Arg stimulates actin polymerization and cellular protrusion has not yet been fu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Cell Adhesion
Share to Cell Surface Extensions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Multimerization

Share to Protein Structure, Quaternary

Share to Protein Transport

Share to Protein-Tyrosine Kinases

Share to src Homology Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 20146487
DOI: 10.1021/bi901721u
PMCID: PMC2836179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20146487-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of actin polymerization and adhesion-dependent cell edge protrusion by the Abl-related gene (Arg) tyrosine kinase and N-WASp.PMID 20146487Read ↗

Crk and Abi1: Binary Molecular Switches That Regulate Abl Tyrosine Kinase and Signaling to the CytoskeletonSemantic proximity Read ↗

ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner.Semantic proximity Read ↗

Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complexSemantic proximity Read ↗

Phosphorylation of GMFγ by c-Abl coordinates lamellipodial and focal adhesion dynamicsSemantic proximity Read ↗

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.Semantic proximity Read ↗

Structure and physiological investigation of arginylated actinSemantic proximity Read ↗

Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled.Semantic proximity Read ↗

Mitotic phosphorylation rescues Abl from F-actin-mediated inhibition.Semantic proximity Read ↗

EPH Receptor Tyrosine Kinases Regulate Epithelial Morphogenesis and Phosphorylate the PAR-3 Scaffold Protein to Modulate Downstream Signaling NetworksSemantic proximity Read ↗

WHIMP links the actin nucleation machinery to Src-family kinase signaling during protrusion and motilitySemantic proximity Read ↗

β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells.Semantic proximity Read ↗

Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of Enabled.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.