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Article

Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative.

Cancer research - 1 Aug 2011

Biddle Adrian, Liang Xiao, Gammon Luke, Fazil Bilal, Harper Lisa J, Emich Helena, Costea Daniela Elena, Mackenzie Ian C

Abstract excerpt

Epithelial-to-mesenchymal transition (EMT) is an important driver of tumor invasion and metastasis, which causes many cancer deaths. Cancer stem cells (CSC) that maintain and initiate tumors have also been implicated in invasion and metastasis, but whether EMT is an important contributor to CSC function is unclear. In this study, we investigated whether a population of CSCs that have undergone EMT (EMT CSCs)...

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Identifiers

PMID: 21685475
DOI: 10.1158/0008-5472.CAN-11-1059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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