Article
Association between brain-derived neurotrophic factor gene and a severe form of bipolar disorder, but no interaction with the serotonin transporter gene.
Bipolar disorders - 1 Jul 2008
Vincze Ilona, Perroud Nader, Buresi Catherine, Baud Patrick, Bellivier Frank, Etain Bruno, Fournier Claire, Karege Felicien, Matthey Marie-Louise, Preisig Martin, Leboyer Marion, Malafosse Alain
Abstract excerpt
BACKGROUND: Recent data suggest that brain-derived neurotrophic factor (BDNF) and the serotonergic system are involved and interact in major depressive disorder and suicidal behavior (SB). Several family and population-based studies have reported associations between the BDNF gene and serotonin-related genes, specifically the serotonin transporter (5HTT) gene, with bipolar disorder (BD) and SB. However, despite...
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